Sources in Germany

Injections vs Gel

How to inject

For more details, refer to Trans Resources or the DIY HRT Directory | Transfem Guide

Small timing variations (±12–24 hours) usually cause only minor fluctuations in estradiol levels due to the long half-life and gradual absorption of EV, especially via the subcutaneous route.

Routes

Subcutaneous

Video

How to Give a Subcutaneous Injection Video - YouTube
or
Hormone Self-Injection - Step 1: Drawing Up - YouTube
Hormone Self-Injection - Step 2b: Subcutaneous Injection - YouTube

Step by Step guide

Subcutaneous Injection: Definition and Patient Education

Tips

Inject slowly
Leave the needle at least 10 seconds in the skin after injecting before pulling out
Put soft preassure on the injection site with a swab after pulling out
Massage gently after injection

Zyklusverschiebung

2025-11 - normally 4 mg EV

estradiol pharmacokinetics playground - estrannaise.js

2025-11-16

4 mg

2025-11-20

2,5 mg

2025-11-23

4 mg

2025-11-27

Blood sample
4 mg

EV → EEN

estradiol pharmacokinetics playground - estrannaise.js

2026-01-24_Sa

3 mg EV

2026-01-28_We

4,84 mg EEN

2026-02-01_Su

3,96 mg EEN

2026-02-08_Su